Electrical power and discharges have been used for decades in electro-surgery for blood coagulation, tissue removal, etc. Plasma scientists have recently realized that low temperature plasmas are quite useful for various other medical treatments, including hand/skin sterilization, wound healing, cell apoptosis/regeneration, and so on. These applications of low temperature plasmas represent an emerging and rapidly growing frontier in low temperature plasma science and technology. A deeper understanding of the nature of these phenomena is indispensable for future technological development. We are collaborating with engineers, biologists, and medical doctors around the world in this rapidly growing and very promising new area.
Plasma-assisted gene transfection against breast cancer
Atmospheric pressure plasmas for Onychomycosis (Fungal nail) treatment
(Zilan Xiong, Jeff Roe, Tim Grammar)
Onychomycosis is a common fungal infection of the nail with significant barriers to successful treatment. The prevalence of onychomycosis is estimated to affect 10% of the world’s adult population , particularly the elderly and patients with immunodeficiency diseases such as HIV, diabetes and circulatory disorders. Contributing to treatment difficulty is the challenge of getting topical antifungal agents through the nail.The Onychomycosis healing ratio is lower than 10% by current treatment options. Systemic oral medications have a higher cure rate, but cost and toxic side effects (e.g. liver problems) are both serious concerns.
Nonthermal plasma in air generates antimicrobial reactive oxygen and nitrogen species at near-room temperature. Reactive plasma species, at the moderate concentrations and doses found in nonthermal plasma streams, appear to cause little to no permanent damage to living tissue, while being capable of efficiently destroying microbial cells. Our study focuses on using atmospheric pressure plasma to treat Onychomycosis. This project is cooperated with DeviceFarm founded by Dr. Jeff Roe and Dr. Tim Grammar.
Disinfection of contact lenses by using atmospheric pressure plasma (Zilan Xiong)
A contact lens, or simply contact, is a thin lens placed directly on the surface of the eye. Directly to the eyeball, it may cause some eye infection disease by bacteria, fungus, virus, Acanthamoeba, etc. A typical example of eye infection disease by wearing contact lenses is keratitis. The existing disinfection solutions or devices like Multipurpose solutions, Saline solution, Daily cleaner, Hydrogen peroxide systems, Enzymatic cleaner, Ultraviolet, vibration or ultrasound devices. Aiming to develop a novel, high efficiency, easy taken, cheap, and convenient disinfection device by using atmospheric pressure air plasma. This project is found by the world's third largest contact company.-CooperVision.
Uptake and diffusion modeling of plasma generated reactive species into biomaterial
Recently, plasma interactions with biomaterial have attracted great interest in the field of plasma medicine. In spite of their importance, our limited knowledge in this research area prevent us to understand the basic physicochemical phenomena for the potential applications. To address this issue, this work focuses on numerical modeling for plasma interactions with biomaterial in order to elucidate the basic behavior for diffusion and uptake of plasma generated reactive species into biomaterial.
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