Ambient-Gas Plasma Disinfection (Matt Pavlovich, Pritha Hait, Connor Galleher, Toshi Ono, Zdenko Machala)
Within the last fifteen years, low-temperature, atmospheric-pressure air plasma has been shown to have toxic effects against a variety of bacteria and other microorganisms. We study the application of air plasma as a means of disinfecting surfaces and liquids. Currently, we are working to understand the relationship among plasma processing parameters, plasma chemistry, and microbial killing; we also aim to elucidate the biochemical and genetic effects of plasma treatment. An eventual goal of the project is to develop a low-cost, portable plasma sterilizer suitable for use in the developing world or emergency medicine. In collaboration with Prof. Douglas Clark, UC Berkeley Department of Chemical and Biomolecular Engineering.
Advanced cancer therapy using plasma-generated ROS/RNS (Sharmin Karim)
Increased levels of reactive oxygen species (ROS) are a hallmark of many types of cancers. This is thought to promote cancer mutation and adaptation to treatment strategies. Many promising new therapies seek to introduce additional ROS into cancer cells, pushing them over the limit into senescence and cell death while normal cells, with lower ROS levels, are unaffected. Plasmas are a promising source of ROS for this purpose. We seek to evaluate the effect of plasma treatment on cancerous and normal cells and to investigate the molecular mechanisms responsible for the differential effects. In collaboration with Prof. Douglas Clark, UC Berkeley Department of Chemical and Biomolecular Engineering.
Synergistic Effects of Plasma and UV (Matt Pavlovich)
High-energy photons at specific wavelengths can interact with plasma-generated species to create biologically relevant reactive species. We study the chemistry and antibacterial effects of combined plasma-photon treatments. In collaboration with Profs. Gary Eden and Sung-Jin Park, University of Illinois.
Interaction of ambient-air plasma with biomolecules (Carly Anderson, Zdenko Machala, Matt Pavlovich)
In plasma medicine, the therapeutic activity of plasma treatment is generally attributed to the generation and delivery of reactive oxygen and nitrogen species (RONS). However, the interaction of plasma-generated species with biomolecules remains poorly understodd. We study the interactions of ambient-temperature plasma with aqueous solutions and simple biomolecules to better understand what modifications to these species occur. This knowledge will help us to tailor plasma devices for more effective treatment.
Discharge Mechanisms of an Atmospheric-Pressure Plasma Needle (Yuki Sakiyama)
In collaboration with Dr. Volker Schulz-von der Gathen, Ruhr-Universitaet Bochum.
Ozone UV Spectroscopy in Surface Micro-Discharge (Dustin Chen, Yuki Sakiyama)
In collaboration with Prof. Gregor Morfill, UC Berkeley Department of Chemical and Biomolecular Engineering.
Finite-Element Modeling of a Plasma Reactor (Emi Kawamura)
A fast 2D hybrid fluid-analytical TCP reactor model was developed using the finite elements simulation tool COMSOL. A gas flow model solves for the steady-state pressure, temperature and velocities of neutral species. By varying the reactor parameters, we can observe their effect on plasma characteristics such as density, uniformity, capacitive coupling and the E to H transition. We would like to extend the model by adding more gases (currently, Ar/O2/Cl2), a matching network circuit, and multi-frequency sheaths. We would also like to couple the fluid-analytical code to particle codes to obtain the ion energy and angular distributions at the wafer. In collaboration with Prof. Mike Lieberman, UC Berkeley Department of Electrical Engineering and Computer Science.
Generation of Underwater Microplasma (Dustin Chen, Pritha Hait, Yuki Sakiyama)